DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
نویسندگان
چکیده
منابع مشابه
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 ...
متن کاملLIGHT-deficiency impairs CD8+ T cell expansion, but not effector function.
LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T cell functions, we generated LIGHT-deficient (LIGHT(-/-)) mice using gene targeting. Disruption of LIGHT significantly reduced CD8(+) T cell-cycle progression, leading to reduced proliferation to anti-CD3, anti-CD3/anti-CD28 or allogeneic st...
متن کاملDeath and Enhances T Cell Survival ORAI1 Deficiency Impairs Activated T Cell
ORAI1 is a pore subunit of Ca 2+ release-activated Ca 2+ channels that mediate TCR stimulation-induced Ca 2+ entry. A point mutation in ORAI1 (ORAI1 R91W) causes SCID in human patients that is recapitulated in Orai1 2/2 mice, emphasizing its important role in the immune cells. In this study, we have characterized a novel function of ORAI1 in T cell death. CD4 + T cells from Orai1 2/2 mice showe...
متن کاملInterleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium.
RATIONALE Endothelial progenitor cell (EPC) survival and function in the injured myocardium is adversely influenced by hostile microenvironment such as ischemia, hypoxia, and inflammatory response, thereby compromising full benefits of EPC-mediated myocardial repair. OBJECTIVE We hypothesized that interleukin-10 (IL-10) modulates EPC biology leading to enhanced survival and function after tra...
متن کاملFancb deficiency impairs hematopoietic stem cell function
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure, variable congenital malformations and a predisposition to malignancies. FANCB (also known as FAAP95), is the only X-linked FA gene discovered thus far. In the present study, we investigated hematopoiesis in adult Fancb deficient (Fancb(-/y)) mice and found that Fancb(-/y) mice have decreased hematopoietic stem cell ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2011
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20110345